TBI & Post Concussion Syndrome

Traumatic brain injury (TBI) is the leading cause of death and disability in the US. Approximately 70-90% of the TBI cases are classified as mild, and up to 25% of them will not recover and suffer chronic neurocognitive impairments. Recent studies have shown that hyperbaric oxygen treatment (HBOT) can induce neuroplasticity leading to significant neurological improvement and repair of chronically impaired brain functions, and improved quality of life in mTBI patients with prolonged PCS at late chronic stage.

Data and Studies from The Sagol Center

Amir Hadanny, Merav Catalogna, Slava Yaniv, Orit Stolar, Lynn Rothstein, Adi Shabi, Gil Suzin, Efrat Sasson, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Ruth Tock Harpaz, Moran Adler, Ron-El Goldman, Yonatan Zemel, Yair Bechor and Shai Efrati
Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial
Scientific Reports volume 12, Article number: 15233 (September 2022)
Boussi-Gross, R., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, J. Bergan, M. Friedman, D. Hoofien, N. Shlamkovitch, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial
PLoS One 8, no. 11 (2013): e79995.
Efrati, S. and E. Ben-Jacob.
Reflections on the Neurotherapeutic Effects of Hyperbaric Oxygen
Expert Rev Neurother 14, no. 3 (Mar 2014): 233-6.
Hadanny, A., S. Abbott, G. Suzin, Y. Bechor, and S. Efrati.
Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis
BMJ Open 8, no. 9 (Sep 28 2018): e023387.
Hadanny, A. and S. Efrati.
Treatment of Persistent Post-Concussion Syndrome Due to Mild Traumatic Brain Injury: Current Status and Future Directions
Expert Rev Neurother 16, no. 8 (Aug 2016): 875-87.
Hadanny, A., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, G. Suzin, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Can Induce Neuroplasticity and Improve Cognitive Functions of Patients Suffering from Anoxic Brain Damage
Restor Neurol Neurosci 33, no. 4 (2015): 471-86.
Tal, S., A. Hadanny, N. Berkovitz, E. Sasson, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen May Induce Angiogenesis in Patients Suffering from Prolonged Post-Concussion Syndrome Due to Traumatic Brain Injury
Restor Neurol Neurosci 33, no. 6 (2015): 943-51.
Tal, S., A. Hadanny, E. Sasson, G. Suzin, and S. Efrati.
Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients
Front Hum Neurosci 11 (2017): 508.

More Studies

Daly, S., M. Thorpe, S. Rockswold, M. Hubbard, T. Bergman, U. Samadani, and G. Rockswold.
Hyperbaric Oxygen Therapy in the Treatment of Acute Severe Traumatic Brain Injury: A Systematic Review
J Neurotrauma 35, no. 4 (Feb 15 2018): 623-29.