This section contains medical information and is intended for healthcare professionals only.
Back to client websiteCognitive Performance and Aging
Age-related cognitive and functional decline has become a significant concern in the Western world. More than half of community-dwelling individuals, sixty years, and older, express concern about declining physical and cognitive abilities. Major research efforts around the world are focused on improving cognitive performance of the so-called 'normal' aging population. Over years of research, there is growing evidence from clinical studies that HBOT, utilized in a repeated daily sessions protocol, has neurotherapeutic effects which can improve and restore cognitive brain functions.
Data and Studies from The Sagol Center
- Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial
BMC Geriatrics, Volume 24, article number 572, (2024)
- Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial
Aging. June 26, 2020
- Hyperbaric Oxygen Therapy Ameliorates Pathophysiology of 3xtg-Ad Mouse Model by Attenuating Neuroinflammation
Neurobiol Aging 62 (Feb 2018): 105-19.
- Hyperbaric Oxygen Therapy as a New Treatment Approach for Alzheimer’s Disease
Neural Regen Res 13, no. 5 (May 2018): 817-18.
- The Hyperoxic-Hypoxic Paradox
Biomolecules. June 25, 2020
- Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial
Aging. November 24, 2021
- Hyperbaric Oxygen Treatment – From Mechanisms to Cognitive Improvement
Biomolecules, 2021 Oct 15
- Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative Stress
Biomolecules, 2021, December 3
- Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial
Aging. November 18, 2020
- Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients
Aging. September 9, 2021
- The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial
Aging, September 16, 2021
More Studies
- Regenerative Longevity Medicine: Hyperbaric Oxygen Therapy as a Cornerstone for Healthy Aging
Stem Cell & Regenerative Medicine, 2025; 9(1): 1-2
- The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length – The difference between zero and one: A case report
- Hyperbaric Oxygen Therapy for Alzheimer’s Dementia with Positron Emission Tomography Imaging: A Case Report
Med Gas Res 8, no. 4 (Oct-Dec 2018): 181-84.
- Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Patients with Vascular Dementia
Cell Transplant 28, no. 8 (Aug 2019): 1071-75.
- Hyperbaric Oxygen Pretreatment Improves Cognition and Reduces Hippocampal Damage Via P38 Mitogen-Activated Protein Kinase in a Rat Model
Yonsei Med J 58, no. 1 (Jan 2017): 131-38.
- Cognitive Enhancement of Healthy Young Adults with Hyperbaric Oxygen: A Preliminary Resting-State Fmri Study
Clin Neurophysiol 126, no. 11 (Nov 2015): 2058-67.
- Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-Beta Generation in Mice
J Alzheimers Dis 37, no. 2 (2013): 325-33.
- Hyperoxygenation Effect on Cognitive Functioning in the Aged
N Engl J Med 281, no. 14 (Oct 2 1969): 753-7.